Recombinant Human TXNRD2, His-tagged

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Recombinant Human TXNRD2, His-tagged

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Cat.No. : TXNRD2-31640TH
Product Overview : Recombinant full length Human TXNRD2 with N terminal His tag
Description : Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
Conjugation : HIS
Source : E. coli
Tissue specificity : Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
Form : Lyophilised
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20mM HEPES, pH 7.4
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Gene Name : TXNRD2 thioredoxin reductase 2 [ Homo sapiens ]
Official Symbol : TXNRD2
Synonyms : TXNRD2; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase beta; TR; TR3; TRXR2;
Gene ID : 10587
mRNA Refseq : NM_006440
Protein Refseq : NP_006431
MIM : 606448
Uniprot ID : Q9NNW7
Chromosome Location : 22q11.21
Pathway : Oxidative Stress, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem;
Function : NADP binding; flavin adenine dinucleotide binding; oxidoreductase activity; protein binding; protein homodimerization activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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