Recombinant Human UBA6, FLAG-tagged

• Cat.No.: UBA6-31449TH
• Product Overview: Recombinant full length Human Uba6 with N-terminal Flag tag, expressed in a Baculovirus infected Sf9 cell expression system; MWt 118 kDa.

Specification

• Description: Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al.
• Conjugation: FLAG
• Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
• Form: Liquid
• Storage buffer: pH: 8.00Constituents:0.05% Tween, 0.0462% DTT, 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl
• Storage: Store at -80°C
• Sequence Similarities: Belongs to the ubiquitin-activating E1 family.

Gene Information

• Gene Name: UBA6 ubiquitin-like modifier activating enzyme 6 [ Homo sapiens ]
• Official Symbol: UBA6
• Synonyms: UBA6; ubiquitin-like modifier activating enzyme 6; UBE1L2, ubiquitin activating enzyme E1 like 2; ubiquitin-like modifier-activating enzyme 6; FLJ10808; ubiquitin activating enzyme E1
• Gene ID: 55236
• mRNA Refseq: NM_018227
• Protein Refseq: NP_060697
• MIM: 611361
• Uniprot ID: A0AVT1
• Chromosome Location: 4q13.2
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem
• Function: ATP binding; FAT10 activating enzyme activity; ligase activity; nucleotide binding; protein binding