"Tek" Related Products


Recombinant Mouse Endothelial-specific Receptor Tyrosine Kinase

Cat. No.: Tek-1779M
Description: Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie-2) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo. They are expressed almost exclusively in endothelial cells. Tie-2 is functional in pericytes and may play an important role in the progression of diabetic retinopathy, by regulating pericyte loss and influencing the activation state and recruitment of pericytes. Tie has been shown to be up-regulated in psoriasis and in breast cancer tissue and blocking Tie2 action inhibits tumor angiogenesis and tumor growth.
Source: NSO Cells.
Molecular Weight: The predicted molecular weight of Recombinant Mouse Tie-2 is Mr 107.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 125-135 kDa.
State Of Matter: Lyophilized
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: Tek endothelial-specific receptor tyrosine kinase [ Mus musculus ]
Synonyms: Tek; endothelial-specific receptor tyrosine kinase; Hyk; Tie2; tie-2; Cd202b; AA517024
Gene ID: 21687
mRNA Refseq: NM_013690
Protein Refseq: NP_038718
UniProt ID: Q02858
Chromosome Location: 4 43.6 cM
Function: ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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