Recombinant Human UGT1A6
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Cat.No. : | UGT1A6-31663TH |
Product Overview : | Recombinant full length UGT1A6 protein (Human) |
Description : | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants. |
Tissue specificity : | Expressed in skin, kidney and liver. |
Biological activity : | Vial Content: 5 mg protein.concentration: 2-20 mg/mL protein |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 100mM Potassium phosphate, 1mM DTT, 0.1mM EDTA, pH 7.4 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | DKLL VVPQDGSHWL SMKDIVEVLS DRGHEIVVVV PEVNLLLKES KYYTRKIYPV PYDQEELKNR YQSFGNNHFA ERSFLTAPQT EYRNNMIVIG LYFINCQSLL QDRDTLNFFK ESKFDALFTD PALPCGVILA EYLGLPSVYL FRGFPCSLEH TFSRSPDPVS YIPRCYTKFS DHMTFSQRVA NFLVNLLEPY LFYCLFSKYE ELASAVLKRD VDIITLYQKV SVWLLRYDFV LEYPRPVMPN MVFIGGINCK KRKDLSQEFE AYINASGEHG IVVFSLGSMV SEIPEKKAMA IADALGKIPQ TVLWRYTGTR PSNLANNTIL VKWLPQNDLL GHPMTRAFIT HAGSHGVYES ICNGVPMVMM PLFGDQMDNA KRMETKGAGV TLNVLEMTSE DLENALKAVI NDKSYKENIM RLSSLHKDRP VEPLDLAVFW VEFVMRHKGA PHLRPAAHDL TWYQYHSLDV IGFLLAVVLT VAFITFKCCA YGYRKCLGKK GRVKKAHKSK TH |
Sequence Similarities : | Belongs to the UDP-glycosyltransferase family. |
Gene Name : | UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 [ Homo sapiens ] |
Official Symbol : | UGT1A6 |
Synonyms : | UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F; |
Gene ID : | 54578 |
mRNA Refseq : | NM_001072 |
Protein Refseq : | NP_001063 |
MIM : | 606431 |
Uniprot ID : | P19224 |
Chromosome Location : | 2q37 |
Pathway : | Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => |
Function : | enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; NOT retinoic acid binding; |
◆ Recombinant Protein
UGT1A6-96H | Recombinant Human UGT1A6 Protein | +Inquiry |
UGT1A6-208H | Recombinant Human UGT1A6, GST-tagged | +Inquiry |
UGT1A6-7719Z | Recombinant Zebrafish UGT1A6 | +Inquiry |
UGT1A6-6432R | Recombinant Rat UGT1A6 Protein | +Inquiry |
UGT1A6-2517H | Recombinant Human UGT1A6 protein, His-tagged | +Inquiry |
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◆ Lysates
UGT1A6-511HCL | Recombinant Human UGT1A6 293 Cell Lysate | +Inquiry |
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UGT2B10 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B4 UGT1A7 UGT2B15 UGT2B17 UGT2B7 UGT3A1 UGT3A2 UGT1A4 UGT1A5 UGT2A3 UGT2B11 Ugt8a Ugt1a2 Ugt1a6a Ugt1a7c UGT1A8 UGT2A1 Ugt2b5 UGT8 Ugt1a6b Ugt2a2 Ugt2b1 UGT2B28 Ugt2b34 Ugt2b35 Ugt2b36 Ugt2b37 Ugt2b38 Ugt2b
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