Recombinant Mouse Tgfbr1 Protein, Fc-tagged
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|Product Overview :||Recombinant mouse TGF-beta RI (Ala21-Glu121) & (Thr22-Glu121) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).|
|Description :||This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants.|
|Source :||Insect cell|
|Form :||Disulfide-linked homodimer|
|Bio-activity :||Measured by its binding ability in a functional ELISA. When Recombinant Rat Endoglin/CD105 Fc Chimera or Recombinant Mouse Endoglin/CD105 Fc Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 0.25-1.25 μg/mL.|
|Molecular Mass :||37.5 kDa (monomer)|
|N-terminal Sequence Analysis :||Ala21 & Thr22|
|Endotoxin :||<0.1 EU/μg of the protein by the LAL method.|
|Purity :||>90% by SDS-PAGE under reducing conditions and visualized by silver stain.|
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Storage Buffer :||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution :||Reconstitute at 500 μg/mL in sterile PBS.|
|Shipping :||The product is shipped at ambient temperature.|
|Gene Name :||Tgfbr1 transforming growth factor, beta receptor I [ Mus musculus (house mouse) ]|
|Official Symbol :||Tgfbr1|
|Synonyms :||Tgfbr1; transforming growth factor, beta receptor I; AL; Alk; ALK5; ESK2; Tbet; Alk-5; Tbeta; TGFR-1; TbetaRI; AU017191; TbetaR-I; TGF-beta receptor type-1; TGF-beta receptor type I; transforming growth factor-beta receptor type I; EC 188.8.131.52|
|Gene ID :||21812|
|mRNA Refseq :||NM_009370|
|Protein Refseq :||NP_033396|
|UniProt ID :||Q64729|
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