Recombinant Mouse Tgfbr1 Protein, Fc-tagged


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Recombinant Mouse Tgfbr1 Protein, Fc-tagged

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Cat.No. : Tgfbr1-1777M
Product Overview : Recombinant mouse TGF-beta RI (Ala21-Glu121) & (Thr22-Glu121) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).
Description : This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants.
Source : Insect cell
Species : Mouse
Tag : Fc
Form : Disulfide-linked homodimer
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Rat Endoglin/CD105 Fc Chimera or Recombinant Mouse Endoglin/CD105 Fc Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 0.25-1.25 μg/mL.
Molecular Mass : 37.5 kDa (monomer)
N-terminal Sequence Analysis : Ala21 & Thr22
Endotoxin : <0.1 EU/μg of the protein by the LAL method.
Purity : >90% by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 500 μg/mL in sterile PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : Tgfbr1 transforming growth factor, beta receptor I [ Mus musculus (house mouse) ]
Official Symbol : Tgfbr1
Synonyms : Tgfbr1; transforming growth factor, beta receptor I; AL; Alk; ALK5; ESK2; Tbet; Alk-5; Tbeta; TGFR-1; TbetaRI; AU017191; TbetaR-I; TGF-beta receptor type-1; TGF-beta receptor type I; transforming growth factor-beta receptor type I; EC
Gene ID : 21812
mRNA Refseq : NM_009370
Protein Refseq : NP_033396
UniProt ID : Q64729

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