Active Recombinant Mouse Tgfbr1 Protein, Fc-tagged

• Cat.No.: Tgfbr1-1777M
• Product Overview: Recombinant mouse TGF-beta RI (Ala21-Glu121) & (Thr22-Glu121) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).

Specification

• Description: This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants.
• Source: Insect cell
• Species: Mouse
• Tag: Fc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Rat Endoglin/CD105 Fc Chimera or Recombinant Mouse Endoglin/CD105 Fc Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 0.25-1.25 μg/mL.
• Molecular Mass: 37.5 kDa (monomer)
• N-terminal Sequence Analysis: Ala21 & Thr22
• Endotoxin: <0.1 EU/μg of the protein by the LAL method.
• Purity: >90% by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 500 μg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: Tgfbr1 transforming growth factor, beta receptor I [ Mus musculus (house mouse) ]
• Official Symbol: Tgfbr1
• Synonyms: Tgfbr1; transforming growth factor, beta receptor I; AL; Alk; ALK5; ESK2; Tbet; Alk-5; Tbeta; TGFR-1; TbetaRI; AU017191; TbetaR-I; TGF-beta receptor type-1; TGF-beta receptor type I; transforming growth factor-beta receptor type I; EC 2.7.11.30
• Gene ID: 21812
• mRNA Refseq: NM_009370
• Protein Refseq: NP_033396
• UniProt ID: Q64729