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Recombinant Human VRK1 Protein (Full Length), N-His-tagged

Cat.No. : VRK1-31740TH
Product Overview : Recombinant protein of human vaccinia related kinase 1 (VRK1), full length, with N-terminal HIS tag, expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Source : E. coli
Species : Human
Tag : N-His
Molecular Mass : 45.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Gene Name : VRK1 VRK serine/threonine kinase 1 [ Homo sapiens (human) ]
Official Symbol : VRK1
Synonyms : VRK1; VRK serine/threonine kinase 1; PCH1; PCH1A; serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; EC 2.7.11.1
Gene ID : 7443
mRNA Refseq : NM_003384
Protein Refseq : NP_003375
MIM : 602168
UniProt ID : Q99986

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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