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Recombinant Human WRN

Cat.No. : WRN-30699TH
Product Overview : Recombinant fragment of Human Werners syndrome helicase WRN with a proprietary tag: predicted molecular weight 37.84 kDa.
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Description : This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3 to 5 DNA helicase activity, and is also a 3 to 5 exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Protein length : 111 amino acids
Molecular Weight : 37.840kDa inclusive of tags
Source : Wheat germ
Biological activity : useful for Antibody Production and Protein Array
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : NPPVNSDMSKISLIRMLVPENIDTY LIHMAIEILKHGPDSGLQPSCDVNK RRCFPGSEEICSSSKRSKEEVGINT ETSSAERKRRLPVWFAKGSDTSKKL MDKTKRGGLFS
Sequence Similarities : Belongs to the helicase family. RecQ subfamily.Contains 1 3-5 exonuclease domain.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.Contains 1 HRDC domain.
Gene Name : WRN Werner syndrome, RecQ helicase-like [ Homo sapiens ]
Official Symbol : WRN
Synonyms : WRN; Werner syndrome, RecQ helicase-like; Werner syndrome; Werner syndrome ATP-dependent helicase; RECQ3; RECQL2;
Gene ID : 7486
mRNA Refseq : NM_000553
Protein Refseq : NP_000544
MIM : 604611
Uniprot ID : Q14191
Chromosome Location : 8p12
Pathway : Regulation of Telomerase, organism-specific biosystem;
Function : 3-5 DNA helicase activity; 3-5 exonuclease activity; ATP binding; ATP-dependent 3-5 DNA helicase activity; ATP-dependent DNA helicase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic mutations in the WRN gene affect its function? 11/22/2022

Mutations in WRN can disrupt its enzymatic activities, leading to genomic instability and disease.

What are the implications of altered WRN activity in aging and age-related diseases? 02/03/2020

Altered WRN activity is associated with accelerated aging and increased risk of age-related diseases.

What role does WRN play in DNA repair and replication? 06/23/2019

WRN plays a crucial role in both DNA repair and replication processes.

How does WRN deficiency lead to Werner syndrome? 06/09/2019

Deficiency in WRN leads to accelerated aging symptoms in Werner syndrome, due to impaired DNA repair.

What potential therapeutic approaches target WRN for treating Werner syndrome and other age-related conditions? 07/21/2018

Therapies targeting WRN aim to enhance DNA repair mechanisms, potentially treating Werner syndrome and related conditions.

How does WRN interact with other proteins in the maintenance of genomic stability? 07/11/2017

WRN cooperates with other proteins to ensure accurate DNA repair and replication.

What is the primary function of WRN in cellular processes? 07/02/2017

WRN is involved in DNA repair and maintenance of genomic stability.

Customer Reviews (3)

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Reviews
10/15/2022

    Supports our research with high-quality data.

    03/15/2021

      Reliable partner for our protein experiments.

      04/03/2017

        Helps us achieve research milestones consistently.

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