Recombinant Human WWP1, FLAG-tagged

• Cat.No.: WWP1-31531TH
• Product Overview: Recombinant full length Human WWP1 with N terminal Flag tag; MWt 106kDa.

Specification

• Description: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.
• Protein length: 921 amino acids
• Conjugation: FLAG
• Molecular Weight: 106.000kDa inclusive of tags
• Source: Baculovirus
• Form: Liquid
• Storage buffer: pH: 8.00Constituents:20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Tween, 0.0462% DTTNote: 103 μg/ml FLAG peptide
• Storage: Store at -80°C

Gene Information

• Gene Name: WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens ]
• Official Symbol: WWP1
• Synonyms: WWP1; WW domain containing E3 ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase WWP1; AIP5; DKFZP434D2111
• Gene ID: 11059
• mRNA Refseq: NM_007013
• Protein Refseq: NP_008944
• MIM: 602307
• Uniprot ID: Q9H0M0
• Chromosome Location: 8q21
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem
• Function: acid-amino acid ligase activity; ligase activity; protein binding; ubiquitin-protein ligase activity; ubiquitin-protein ligase activity