Cat. No. :	PNMT-481H
Product Overview :	Recombinant human PNMT protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 30.8 Da (282aa).
Description :	PNMT, also known as phenylethanolamine N-methyltransferase, is an enzyme found in the adrenal medulla that catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production.
Source :	E.coli.
Amino Acid Sequence :	MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
Form :	Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity :	> 95% by SDS – PAGE.
Concentration :	1.0 mg/ml (determined by Bradford assay).
Storage :	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Publication :	Noncompetitive Inhibition of Indolethylamine N-Methyltransferase by N, N Dimethyltryptamine (DMT) and N, N-Dimethylaminopropyltryptamine

Gene Name :	PNMT phenylethanolamine N-methyltransferase [ Homo sapiens ]
Synonyms :	PNMT; phenylethanolamine N-methyltransferase; PENT; PNMTase; MGC34570; phenylethanolamine N-methyltransferase; phenylethanolamine N-methylase; noradrenaline N-methyltransferase; EC 2.1.1.28; OTTHUMP00000164271
Gene ID :	5409
mRNA Refseq :	NM_002686
Protein Refseq :	NP_002677
MIM :	171190
UniProt ID :	P11086
Chromosome Location :	17q21-q22
Pathway :	Metabolic pathways; Tyrosine metabolism
Function :	methyltransferase activity; phenylethanolamine N-methyltransferase activity; transferase activity

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