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Recombinant Human Phenylethanolamine N-methyltransferase

Cat. No.: PNMT-481H
Product Overview: Recombinant human PNMT protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 30.8 Da (282aa).
Description: PNMT, also known as phenylethanolamine N-methyltransferase, is an enzyme found in the adrenal medulla that catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production.
Source: E.coli.
Amino Acid Sequence: MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity: > 95% by SDS – PAGE.
Concentration: 1.0 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PNMT phenylethanolamine N-methyltransferase [ Homo sapiens ]
Synonyms: PNMT; phenylethanolamine N-methyltransferase; PENT; PNMTase; MGC34570; phenylethanolamine N-methyltransferase; phenylethanolamine N-methylase; noradrenaline N-methyltransferase; EC 2.1.1.28; OTTHUMP00000164271
Gene ID: 5409
mRNA Refseq: NM_002686
Protein Refseq: NP_002677
MIM: 171190
UniProt ID: P11086
Chromosome Location: 17q21-q22
Pathway: Metabolic pathways; Tyrosine metabolism
Function: methyltransferase activity; phenylethanolamine N-methyltransferase activity; transferase activity

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