Cat. No.:	PNMT-481H
Product Overview:	Recombinant human PNMT protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 30.8 Da (282aa).
Description:	PNMT, also known as phenylethanolamine N-methyltransferase, is an enzyme found in the adrenal medulla that catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production.
Source:	E.coli.
Amino Acid Sequence:	MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
Form:	Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity:	> 95% by SDS – PAGE.
Concentration:	1.0 mg/ml (determined by Bradford assay).
Storage:	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Name:	PNMT phenylethanolamine N-methyltransferase [ Homo sapiens ]
Synonyms:	PNMT; phenylethanolamine N-methyltransferase; PENT; PNMTase; MGC34570; phenylethanolamine N-methyltransferase; phenylethanolamine N-methylase; noradrenaline N-methyltransferase; EC 2.1.1.28; OTTHUMP00000164271
Gene ID:	5409
mRNA Refseq:	NM_002686
Protein Refseq:	NP_002677
MIM:	171190
UniProt ID:	P11086
Chromosome Location:	17q21-q22
Pathway:	Metabolic pathways; Tyrosine metabolism
Function:	methyltransferase activity; phenylethanolamine N-methyltransferase activity; transferase activity

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