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Recombinant Human Collagen, Type VI, Alpha 1

Cat. No. : COL6A1-1870H
Product Overview : Recombinant Human COL6A1 was expressed inE.Coli.
Description : Collagens are major fibrous structural elements of cartlilage, tendon, bone, skin, lung, and blood vessels. Type III collagen consists of three alpha1(III) chains and is most often found in skin, blood vessels, and internal organs. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Formulation : Collagen-VI at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability : Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name : COL6A1 collagen, type VI, alpha 1 [ Homo sapiens ]
Synonyms : collagen, type VI, alpha 1; OPLL; COL6A1; collagen alpha-1(VI) chain; alpha 1 (VI) chain (61 AA); collagen VI, alpha-1 polypeptide;human mRNA for collagen VI alpha-1 C-terminal globular domain9
Gene ID : 1291
mRNA Refseq : NM_001848.2
Protein Refseq : NP_001839.2
MIM : 120220
UniProt ID : P12109
Chromosome Location : 21q22.3
Pathway : ECM-receptor interaction; Focal adhesion; Axon guidance; Signaling by PDGF
Function : platelet-derived growth factor binding; molecular_function; protein binding

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