Recombinant Human EPH Receptor A2, His-tagged

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Recombinant Human EPH Receptor A2, His-tagged

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Cat. No. : EPHA2-541H
Product Overview : Recombinant human EPHA2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=47kDa.
Description : EPHA2 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process that can be reversed by ligation of EPHA2.
Source : Sf9 insect cells.
Purity : >90%.
Specific Activity : 170 U/mg. One unit is defined as the amount of enzyme that will phosphorylate 1 nmol of tyrosine substrate per minute at pH 7.4 and 30ºC. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 0.1 mM ATP, 30 μg/ml Poly (Glu:Tyr) 4:1 substrate, and 0.1 μg /ml recombinant EPHB2.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT.
Stability : >12 months at –80°C.
PDB rendering based on 1mqb. :

Gene Name : EPHA2 EPH receptor A2 [ Homo sapiens ]
Synonyms : EPHA2; EPH receptor A2; ECK; ARCC2; protein tyrosine kinase; soluble EPHA2 variant 1; soluble EPHA2 variant 1; epithelial cell receptor protein tyrosine kinase; ephrin receptor EphA2; EC 2.7.10.1
Gene ID : 1969
mRNA Refseq : NM_004431
Protein Refseq : NP_004422
MIM : 176946
UniProt ID : P29317
Chromosome Location : 1p36
Pathway : Axon guidance
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity

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