Recombinant Canine Interleukin 1, Beta

• Cat.No.: IL1B-243C
• Product Overview: Recombinant Canine IL1B was expressed inYeast. MW= 17.5 kDa (152 aa).

Specification

• Cat. No.: IL1B-243C
• Description: IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.
• Source: Yeast.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: AAMQSVDCKL QDISHKYLVL SNSYELRALH LNGENVNKQV VFHMSFVHGD ESNNKIPVVL GIKQKNLYLS CVMKDGKPTL QLEKVDPKVY PKRKMEKRFV FNKIEIKNTV EFESSQYPNW YISTSQVEGM PVFLGNTRGG QDITDFTMEF SS.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IL1B interleukin 1, beta [ Canis lupus familiaris ]
• Synonyms: interleukin 1, beta; IL1B; IL-1; interleukin-1 beta; IL-1 beta; interleukin-1 beta proprotein
• Gene ID: 403974
• mRNA Refseq: NM_001037971.1
• Protein Refseq: NP_001033060.1
• UniProt ID: Q28292
• Chromosome Location: 17
• Pathway: Alzheimer"s disease; Apoptosis; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Graft-versus-host disease; Hematopoietic cell lineage; MAPK signaling pathway; NOD-like receptor signaling pathway; Prion diseases; Toll-like receptor signaling pathway; Type I diabetes mellitus