Recombinant Human ADAMTS4, His-tagged

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Recombinant Human ADAMTS4, His-tagged

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Cat. No. : ADAMTS4-533H
Product Overview : Recombinant human ADAMTS-1 (residues 213 to 579 of full-length human ADAMTS-4) protein with His tag, was expressed in abaculovirussystem and purified from insect cells, 40 kDa.
Description : Aggrecanases belong to a family of ADAMTS proteases (ADAMTS = A disintegrin and metalloprotease with thrombospondin motifs). ADAMTS enzymes are comprised of an N-terminal prodomain, a catalytic domain, a disintegrin domain, one or more thrombospondin (TS) motifs, a cysteine-rich domain and a spacer domain of variable length. The prodomains are cleaved off intracellularly and the enzymes are processed further from their C-terminal ends after secretion. Aggrecanases are responsible for aggrecan degradation in osteoarthritic joints. ADAMTS-4 (aggrecanase-1) is a major aggrecanase in human osteoarthritic cartilage.5 ADAMTS-4 hydrolyzes also versican and brevican.
Source : Baculovirus.
Activity : Activity (mU/mg) is specified on the vial.
Unit Definition : One milliunit of protease hydrolyzes 1 nanomole of aggrecan interglobular domain substrate per minute at pH 7.5 at 37°C.
Purity : > 90% as estimated by SDS-PAGE.
Formulation : 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05% Brij-35.
Application : Used for screening of ADAMTS-4 inhibitors and for continuous assay of ADAMTS-4 activity and for FRET-based assay.
Storage : Store at -80°C. Avoid multiple thaw-freeze cycles.
Gene Name : ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ]
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC 3.4.24.82
Gene ID : 9507
mRNA Refseq : NM_005099
Protein Refseq : NP_005090
MIM : 603876
UniProt ID : O75173
Chromosome Location : 1q21-q23
Function : metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; zinc ion binding

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