Recombinant Human ADAMTS4, His-tagged


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Recombinant Human ADAMTS4, His-tagged

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Cat. No. : ADAMTS4-533H
Product Overview : Recombinant human ADAMTS-1 (residues 213 to 579 of full-length human ADAMTS-4) protein with His tag, was expressed in abaculovirussystem and purified from insect cells, 40 kDa.
Description : Aggrecanases belong to a family of ADAMTS proteases (ADAMTS = A disintegrin and metalloprotease with thrombospondin motifs). ADAMTS enzymes are comprised of an N-terminal prodomain, a catalytic domain, a disintegrin domain, one or more thrombospondin (TS) motifs, a cysteine-rich domain and a spacer domain of variable length. The prodomains are cleaved off intracellularly and the enzymes are processed further from their C-terminal ends after secretion. Aggrecanases are responsible for aggrecan degradation in osteoarthritic joints. ADAMTS-4 (aggrecanase-1) is a major aggrecanase in human osteoarthritic cartilage.5 ADAMTS-4 hydrolyzes also versican and brevican.
Source : Baculovirus.
Activity : Activity (mU/mg) is specified on the vial.
Unit Definition : One milliunit of protease hydrolyzes 1 nanomole of aggrecan interglobular domain substrate per minute at pH 7.5 at 37°C.
Purity : > 90% as estimated by SDS-PAGE.
Formulation : 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05% Brij-35.
Application : Used for screening of ADAMTS-4 inhibitors and for continuous assay of ADAMTS-4 activity and for FRET-based assay.
Storage : Store at -80°C. Avoid multiple thaw-freeze cycles.
Gene Name : ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ]
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC
Gene ID : 9507
mRNA Refseq : NM_005099
Protein Refseq : NP_005090
MIM : 603876
UniProt ID : O75173
Chromosome Location : 1q21-q23
Function : metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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