Recombinant Human Beta-2-Microglobulin

• Cat.No.: B2M-1905H
• Product Overview: Recombinant Human β2 Microglobulin protein was expressed in insect cells.The expressed protein was purified by a combination of ion-exchange and gel-filtration methods.

Specification

• Cat. No.: B2M-1905H
• Description: The major histocompatibility complex (MHC) gene locus encodes a group of highly polymorphic, cell surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Class I MHC molecules consist of two separate polypeptide chains. The class I α chain is an MHC encoded, transmembrane polypeptide containing three extracellular domains: α1, α2 and α3. The second chain consists of a non-MHC encoded, 12 kDa polypeptide called β2 microglobulin (β2M). Since β2M does not contain a transmembrane domain, it associates with the a chain through non-covalent interaction. This association is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells. β2M is relatively invariant within each species. For example, human β2M is reported to have high affinity for human and mouse MHC class I heavy chains.
• Source: Insect cells.
• Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Lys-Ala-Met-His-Val.
• Concentration: 0.5 mg/ml.
• Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
• Preparation And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Gene Information

• Gene Name: B2M beta-2-microglobulin [ Homo sapiens ]
• Synonyms: B2M; beta-2-microglobulin; Beta-2 microglob ulin form pI 5.3; beta-2-microglobin; beta chain of MHC class I molecules
• Gene ID: 567
• mRNA Refseq: NM_004048
• Protein Refseq: NP_004039
• MIM: 109700
• UniProt ID: P61769
• Chromosome Location: 15q21-q22.2
• Pathway: Antigen processing and presentation; HIV Infection; Signaling in Immune system
• Function: protein binding