Recombinant Human Beta-2-Microglobulin

Cat. No.: B2M-1905H
Product Overview: Recombinant Human β2 Microglobulin protein was expressed in insect cells.The expressed protein was purified by a combination of ion-exchange and gel-filtration methods.
Description: The major histocompatibility complex (MHC) gene locus encodes a group of highly polymorphic, cell surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Class I MHC molecules consist of two separate polypeptide chains. The class I α chain is an MHC encoded, transmembrane polypeptide containing three extracellular domains: α1, α2 and α3. The second chain consists of a non-MHC encoded, 12 kDa polypeptide called β2 microglobulin (β2M). Since β2M does not contain a transmembrane domain, it associates with the a chain through non-covalent interaction. This association is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells. β2M is relatively invariant within each species. For example, human β2M is reported to have high affinity for human and mouse MHC class I heavy chains.
Source: Insect cells.
Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Lys-Ala-Met-His-Val.
Concentration: 0.5 mg/ml.
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
Preparation And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Gene Name: B2M beta-2-microglobulin [ Homo sapiens ]
Synonyms: B2M; beta-2-microglobulin; Beta-2 microglob ulin form pI 5.3; beta-2-microglobin; beta chain of MHC class I molecules
Gene ID: 567
mRNA Refseq: NM_004048
Protein Refseq: NP_004039
MIM: 109700
UniProt ID: P61769
Chromosome Location: 15q21-q22.2
Pathway: Antigen processing and presentation; HIV Infection; Signaling in Immune system
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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