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Recombinant Human Collagen, Type III, Alpha 1

Cat.No. : COL3A1-1957H
Product Overview : Recombinant Human collagen-III encoding proalpha (III) and both alpha and beta subunits of the prolyl hydoxylase were coexpressed in the yeastPichia Pastoris. Procollagen III was converted to mature collagen by controlled proteinase digestion.
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Cat. No. : COL3A1-1957H
Description : Collagen, a major component of the extracellular matrix, is a fibrous protein that provides tensile strength to tissues giving them structural integrity. Collagen and its derivative, gelatin, have been widely used in medical, pharmaceutical and consumer products for more than 100 years. Products that contain animal-derived collagen can induce potentially harmful inflammatory or immune responses in humans and pose risk of contamination with viruses or prions, potentially life-threatening pathogens. Recombinant collagens are essentially identical to the native collagen protein thereby reducing the risk of inflammation, immune response, and disease as compared to animal-sourced collagen.
Source : Pichia Pastoria.
Physical Appearance : Sterile filtered liquid.
Purity : ≥95% as determined by SDS-PAGE.
Formulation : 3.5 mg/ml in 10 mM HCl.
Storage Conditions : Recombinant Human Collagenase-III should be stored at 2-8°C.
Gene Name : COL3A1 collagen, type III, alpha 1 [ Homo sapiens ]
Synonyms : collagen, type III, alpha 1; EDS4A; FLJ34534; COL3A1; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant; collagen type III alpha 1
Gene ID : 1281
mRNA Refseq : NM_000090.3
Protein Refseq : NP_000081.1
MIM : 120180
UniProt ID : P02461
Chromosome Location : 2q31
Pathway : ECM-receptor interaction; Focal adhesion; Axon guidance; Signaling by PDGF
Function : SMAD binding; extracellular matrix structural constituent; integrin binding; platelet-derived growth factor binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How can the study of COL3A1 protein aid in the development of personalized medicine for vEDS patients? 04/12/2023

Understanding the specific genetic and protein alterations in vEDS patients can help tailor individualized treatment strategies based on the patient's unique molecular profile.

Can COL3A1 protein analysis be used for prenatal screening of vEDS? 07/05/2022

Yes, analysis of COL3A1 protein levels in prenatal samples may provide valuable information for assessing the risk of vEDS in the developing fetus.

How can the measurement of COL3A1 protein levels aid in the early detection of vEDS? 03/28/2021

Elevated or decreased levels of COL3A1 protein may serve as potential biomarkers for early detection and risk assessment of vEDS, especially in at-risk individuals or families.

What are the current challenges in the clinical application of COL3A1 protein analysis? 01/08/2020

Challenges include the need for standardized assays and reference ranges for COL3A1 protein levels, as well as the interpretation of results in the context of individual patient variability.

Can the measurement of COL3A1 protein levels be used to monitor disease progression in vEDS patients? 12/31/2019

Yes, monitoring changes in COL3A1 protein levels may provide insights into disease progression and response to treatment in vEDS patients.

Customer Reviews (3)

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Reviews
01/23/2020

    This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

    05/08/2019

      The COL3A1 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      07/27/2016

        the COL3A1 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

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