Recombinant Human NR1I2, Ligand Binding Domain

• Cat.No.: NR1I2-1896H
• Product Overview: Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 2 wasexpressed inE. coli.

Specification

• Cat. No.: NR1I2-1896H
• Description: Nuclear pregnane X receptor (PXR; NR1I2) important component body's adaptive defense mechanism against toxic substances including foreign chemicals (xenobiotics, 2). PXR activated number endogenous exogenous chemicals including steroids, antibiotics, antimycotics, bile, herbal antidepressant St. John's wort. PXR known to regulate several additional genes encoding proteins involved xenobiotic metabolism, including multidrug resistance (MDR1), multidrug resistance-associated 2 (MRP2, 11), organic anion transporter polypeptide 2). Elucidation three-dimensional structure PXR ligand binding revealed it has, spherical ligand binding cavity allows it to interact wide range hydrophobic chemicals. Thus, unlike other nuclear receptors interact selectively their physiological ligands, PXR serves as generalized sensor hydrophobic toxins. PXR binds as heterodimer 9-cis retinoic acid receptor (NR2B) to DNA response elements regulatory regions cytochrome P450 3A monooxygenase genes number other genes involved metabolism elimination xenobiotics body.
• Source: E. coli.
• Application: PXR-LBD ligand binding assays. Research Use Only analysis.
• Formulation: Ligand assay detected immuno-blot .0.5 mg/ml (7.9) EDTA.

Gene Information

• Gene Name: NR1I2 nuclear receptor subfamily 1, group I, member 2 [ Homo sapiens ]
• Synonyms: NR1I2; nuclear receptor subfamily 1, group I, member 2; BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; orphan nuclear receptor PXR; steroid and xenobiotic receptor
• Gene ID: 8856
• mRNA Refseq: NM_003889
• Protein Refseq: NP_003880
• MIM: 603065
• UniProt ID: O75469
• Chromosome Location: 3q12-q13.3
• Pathway: Gene Expression
• Function: metal ion binding; sequence-specific DNA binding; protein binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; transcription repressor activity; zinc ion binding

Reviews

02/22/2023

Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.

03/02/2022

The NR1I2 protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

10/22/2016

In addition to its high-quality attributes, the manufacturer of the NR1I2 protein offers exemplary technical support.

Q&As

Are there any diseases associated with dysregulation of NR1I2?

Dysregulation of NR1I2 has been implicated in certain liver diseases and metabolic disorders, where impaired drug metabolism may contribute to disease progression.

How does NR1I2 influence the efficacy of chemotherapy drugs?

NR1I2 can influence the metabolism of chemotherapy drugs, affecting their bioavailability and efficacy in cancer treatment.

Are there any drugs that specifically target NR1I2 for therapeutic purposes?

Some drugs are designed to modulate NR1I2 activity for therapeutic purposes, aiming to enhance or inhibit its function based on the clinical context.

How does NR1I2 respond to xenobiotic exposure?

NR1I2 is activated in response to xenobiotic exposure, leading to the upregulation of enzymes involved in detoxification and elimination of foreign substances.

Can genetic variations in NR1I2 influence drug response?

Yes, genetic variations in NR1I2 can lead to inter-individual differences in drug metabolism, potentially impacting drug efficacy and safety.