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|Product Overview :
||Full length (2-400aa) recombinant Human SIRT7 expressed inE.coliN-terminal was fused to his-tagged SIRT7. MW = 49.3 kDa.
||The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription of RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
||50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.
||≥6 months at -80°C; avoid freeze/thaw cycles by aliquoting the protein and storing at -80°C.