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Recombinant Human SIRT7, His-tagged

Cat. No. : SIRT7-585H
Product Overview : Full length (2-400aa) recombinant Human SIRT7 expressed inE.coliN-terminal was fused to his-tagged SIRT7. MW = 49.3 kDa.
Description : The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription of RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
Source : E.coli.
Purity : ≥85%.
Formulation : 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.
Stability : ≥6 months at -80°C; avoid freeze/thaw cycles by aliquoting the protein and storing at -80°C.
Gene Name : SIRT7 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) [ Homo sapiens ]
Synonyms : SIRT7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae); SIR2L7; MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; EC 3.5.1.-; sirtuin 7
Gene ID : 51547
mRNA Refseq : NM_016538
Protein Refseq : NP_057622
MIM : 606212
UniProt ID : Q9NRC8
Chromosome Location : 17q25
Function : NAD binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; zinc ion binding

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