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Recombinant Mouse Tnfsf4, FLAG-tagged

Cat.No. : Tnfsf4-2074M
Product Overview : Recombinant Mouse Tnfsf4 is produced inHEK 293 Cells. The extracellular domain of mouse CD134L (OX40L) (aa 52-198) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag. MW=28kDa.
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Cat. No. : Tnfsf4-2074M
Description : OX40L is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. OX40L has also been designated CD252 (cluster of differentiation 252).
Source : HEK 293 Cells.
Purity : ≥90% (SDS-PAGE).
Concentration : 0.1mg/ml after reconstitution.
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 100µl sterile water.
Specificity : Binds to human and mouse CD134 (OX40).
Biological Activity : Activates T cell proliferation.
Storage : -20°C.
Gene Name : Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 [ Mus musculus ]
Synonyms : Tnfsf4; tumor necrosis factor (ligand) superfamily, member 4; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l; Tnfsf4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand
Gene ID : 22164
mRNA Refseq : NM_009452
Protein Refseq : NP_033478
UniProt ID : P43488
Chromosome Location : 1 H2.1; 1 84.9 cM
Pathway : Cytokine-cytokine receptor interaction
Function : cytokine activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic variations in TNFSF4 affect immune function? 01/09/2022

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation? 08/16/2021

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses? 05/11/2020

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders? 09/12/2019

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system? 06/09/2019

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases? 10/04/2018

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation? 03/29/2017

Altered TNFSF4 activity contributes to chronic inflammation.

Customer Reviews (3)

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12/28/2022

    Efficient service, accelerates research productivity.

    05/13/2018

      Outstanding accuracy, essential for research quality.

      02/12/2018

        Trusted for research integrity, a critical research asset.

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