"LTBR" Related Products


Recombinant Human LTBR, FC Chimera

Cat. No. : LTBR-2090H
Product Overview : Recombinant Human LTBR Produced inHEK 293 cells.The cysteine-rich region of human LTβR (aa 1-220) is fused to the Fc portion of human IgG1. MW= Migrates as a doublet at ~56kDa and ~60kDa (SDS-PAGE).
Description : Lymphotoxin beta receptor (LTBR), a receptor for lymphotoxin, is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta).
Source : HEK 293 cells.
Concentration : 1mg/ml after reconstitution.
Purity : ≥95% (SDS-PAGE).
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein.
Reconstitution : Reconstitute in 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Specificity : Binds human and mouse LIGHT and LTα1β2.
Biological Activity : Inhibits human LIGHT- and LTα1β2-mediated effects such as cytotoxic effects on HT29 target cells.
Application : Detection of human membrane-bound LIGHT in combination with PAb to human IgG1.
Long Term Storage :
Handling : Stable for at least 6 months after receipt when stored at -20°C.
Stability : Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Crystallographic structure of LTBR. :

Gene Name : LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ]
Synonyms : LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); CD18; TNFCR; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III; Tumor necrosis factor receptor superfamily member 3; Lymphotoxin-beta receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor C receptor; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
Gene ID : 4055
mRNA Refseq : NM_002342
Protein Refseq : NP_002333
MIM : 600979
UniProt ID : P36941
Chromosome Location : 12p13
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity

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