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Recombinant Human APEX Nuclease 1

Cat. No.: APEX1-593H
Product Overview: Recombinant human APEX1 protein produced inE. coli,36kDa.
Description: Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5" to the AP site, thereby initiating a process known as base excision repair (BER). The APEX gene (alternatively named APE1, HAP1, APEN) encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Source: E. coli.
Concentration: 1 mg/ml.
Purity: ≥95% (SDS-PAGE).
Formulation: Liquid. In 20mM HEPES-KOH, pH 7.5, containing 100mM NaCl and 20% glycerol.
Storage: Enzyme is stable for ~2 weeks at -20°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Pathways: Base excision repair; DNA Repair
Gene Name: APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 [ Homo sapiens ]
Synonyms: APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1; APEX1; DNA-(apurinic or apyrimidinic site) lyase; AP lyase; protein REF-1; redox factor 1; AP endonuclease 1; AP endonuclease class I; apurinic/apyrimidinic exonuclease; multifunctional DNA repair enzyme; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic); EC 4.2.99.18; APEX nuclease (multifunctional DNA repair enzyme);APE-1; REF-1; APEX nuclease 1; APEX nuclease
Gene ID: 328
mRNA Refseq: NM_001641
Protein Refseq: NP_001632
MIM: 107748
UniProt ID: P27695
Chromosome Location: 14q11.2-q12
Function: 3"-5" exonuclease activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; endonuclease activity; lyase activity; metal ion binding; oxidoreductase activity; phosphodiesterase I activity; phosphoric diester hydrolase activity; protein binding; ribonuclease H activity; transcription coactivator activity; transcription corepressor activity; uracil DNA N-glycosylase activity

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