"FURIN" Related Products

Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)

Cat. No.: FURIN-605H
Product Overview: Recombinant Human Furin was produced inDrosophilamelanogasterSchneider2 cells. Corresponds to aa 108-714 of the human preproenzyme. Does not contain the C-terminal and transmembrane domains. MW = 81kDa.
Description: Furin is a protein that in humans is encoded by the FURIN gene. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).
Source: Drosophila melanogaster Schneider 2 cells.
Purity: ~90% (one major band at ~83kDa).
Formulation: Liquid. In 100mM HEPES, pH 7.5, containing 25% glycerol, 150mM sodium chloride and 1mM calcium dichloride.
Quantity: ~50U/vial. One unit is defined as the amount of enzyme that releases 1pmol AMC from Boc-Arg-Val-Arg-Arg-AMC (Prod. No. ALX-260-040) per minute.
Biological Activity: Cleaves precursor proteins C-terminal to an Arg-X-X-Arg motif.
Specific Activity: One unit cleaves 24pmol (2µg) of protective antigen or 100pmol (2.5µg) of human proendothelin-1 per hour at 30°C in 100mM HEPES, pH 7.6, containing 1mM calcium dichloride, 0.5% Triton X-100 and 1mM 2-mercaptoethanol.
Concentration: 1U/µl.
Storage: Do not aliquot. Keep vial on ice during use and put immediately back in -80°C freezer. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Gene Name: FURIN furin (paired basic amino acid cleaving enzyme) [ Homo sapiens ]
Synonyms: FURIN; furin (paired basic amino acid cleaving enzyme); FUR; PACE; SPC1; PCSK3; FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furin, membrane associated receptor protein; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue-cleaving enzyme; EC; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
Gene ID: 5045
mRNA Refseq: NM_002569
Protein Refseq: NP_002560
MIM: 136950
UniProt ID: P09958
Chromosome Location: 15q26.1
Pathway: Metabolism of proteins; Signaling by Notch; Signaling by PDGF; Signaling by TGF beta; Signalling by NGF
Function: endopeptidase activity; metal ion binding; nerve growth factor binding; peptidase activity; peptide binding; protease binding; protein binding; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity

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