Recombinant Human CASP1
Cat.No. : | CASP1-596H |
- Specification
- Gene Information
- Related Products
Cat. No. : | CASP1-596H |
Description : | Caspase-1 is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20kDa) and small (10kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form. |
Sourse/Host : | E. coli. |
Formulation : | Lyophilized. |
Reconstitution : | Reconstitute to 1U/µl with PBS containing 15% glycerol. |
Specific Activity : | ~20'000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate YVAD-pNA (pNA:p-nitroanaline) per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM sodium chloride, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT. |
Application : | Useful in studying enzyme regulation and inhibitors, determining target substrate, screening caspase inhibitors, or as a positive control in caspase assays. We recommend using 1 unit per assay for analyzing caspase activity. |
Storage : | For long term storage, -80°C. |
Pathways : | Amyotrophic lateral sclerosis (ALS); Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway |
Gene Name : | CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) [ Homo sapiens ] |
Synonyms : | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); ICE; P45; IL1BC; CASP1; caspase-1; CASP-1; IL-1BC; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1-beta convertase; interleukin-1 beta convertase; interleukin 1-B converting enzyme; interleukin-1 beta-converting enzyme; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); p45; EC 3.4.22.36 |
Gene ID : | 834 |
mRNA Refseq : | NM_001223 |
Protein Refseq : | NP_001214 |
MIM : | 147678 |
UniProt ID : | P29466 |
Chromosome Location : | 11q23 |
Function : | cysteine-type endopeptidase activity; caspase activator activity; peptidase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
CASP1-1265H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), Tag Free | +Inquiry |
CASP1-0411H | Recombinant Human CASP1 Protein, GST-Tagged | +Inquiry |
CASP1-1240M | Recombinant Mouse CASP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP1-1266H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged | +Inquiry |
CASP1-621H | Recombinant Human CASP1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CASP1-7841HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
CASP1-7840HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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