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Recombinant Mouse Tnfsf18, His-tagged

Cat. No. : Tnfsf18-2130M
Product Overview : Recombinant mouse extracellular domain of GITRL (aa 45-173) produced inE. coliis fused at the C-terminus to a His-tag.
Description : Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Source/Host : E. coli.
Purity : ≥90% (SDS-PAGE).
Concentration : 0.5mg/ml.
Endotoxin Content : <1EU/mg protein (LAL test; Bio Whittaker).
Specificity : Binds to mouse GITR.
Formulation : Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
Application : rmsGITRL can be used for GITR-mediated NF-κB activation.
Long Term Storage : -20°C.
Use/Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Gene Name : Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 [ Mus musculus ]
Synonyms : tumor necrosis factor (ligand) superfamily, member 18; Gitrl; Tnfsf18; GITR ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand
Gene ID : 240873
mRNA Refseq : NM_183391
Protein Refseq : NP_899247
Chromosome Location : 1 H2.1; 1 84.95 cM
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity

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