Recombinant Mouse Tnfsf18, His-tagged

• Cat.No.: Tnfsf18-2130M
• Product Overview: Recombinant mouse extracellular domain of GITRL (aa 45-173) produced inE. coliis fused at the C-terminus to a His-tag.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Protein Length: 45-173 a.a.
• Description: Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
• Source/Host: E. coli.
• Purity: ≥90% (SDS-PAGE).
• Concentration: 0.5mg/ml.
• Endotoxin Content: <1EU/mg protein (LAL test; Bio Whittaker).
• Specificity: Binds to mouse GITR.
• Formulation: Liquid. 0.2µm-filtered solution in 10mM glycin, pH 10.0.
• Application: rmsGITRL can be used for GITR-mediated NF-κB activation.
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Gene Information

• Gene Name: Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 [ Mus musculus ]
• Synonyms: tumor necrosis factor (ligand) superfamily, member 18; Gitrl; Tnfsf18; GITR ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand
• Gene ID: 240873
• mRNA Refseq: NM_183391
• Protein Refseq: NP_899247
• Chromosome Location: 1 H2.1; 1 84.95 cM
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity