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Recombinant Human CASP9

Cat.No. : CASP9-618H
Product Overview : Recombinant Human CARM1 is produced inE. coli.
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  • Gene Information
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Cat. No. : CASP9-618H
Description : Caspase-9 is an initiator caspase encoded by the CASP9 gene. CASP9 orthologs have been identified in all mammals for which complete genome data are available. Unique orthologs are also present in lizards, lissamphibians, and teleosts. The aspartic acid specific protease caspase-9 has been linked to the mitochondrial death pathway. It is activated during programmed cell death (apoptosis). Induction of stress signalling pathways JNK/SAPK causes release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which in turn cleaves the pro-enzyme of caspase-9 into the active form. Once initiated caspase-9 goes on to cleave procaspase-3 & procaspase-7 and which cleave several cellular targets, including poly ADP ribose polymerase.
Source : E. coli.
Storage : -80°C.
Gene Name : CASP9 caspase 9, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms : CASP9; caspase 9, apoptosis-related cysteine peptidase; RP11-265F14.3, APAF-3, APAF3, CASPASE-9c, ICE-LAP6; CASP-9; ICE-like apoptotic protease 6; apoptotic protease MCH-6; apoptotic protease activating factor 3; apoptotic protease-activating factor 3; caspase 9, apoptosis-related cysteine protease; caspase-9; EC 3.4.22.62
Gene ID : 842
mRNA Refseq : NM_001229
Protein Refseq : NP_001220
MIM : 602234
UniProt ID : P55211
Chromosome Location : 1p36.3-p36.1
Pathway : Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Colorectal cancer; Huntington"s disease; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; VEGF signaling pathway; Viral myocarditis; p53 signaling pathway; Signalling by NGF
Function : cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What clinical conditions are associated with dysregulation of CASP9 protein? 10/10/2022

Dysregulation of CASP9 protein is associated with cancer, neurodegenerative diseases, and immune system disorders.

Can CASP9 protein be used as a therapeutic target in autoimmune diseases? 01/16/2021

CASP9 protein is being investigated as a potential therapeutic target in autoimmune diseases to modulate immune cell apoptosis.

How is CASP9 protein implicated in immune system disorders? 10/01/2017

Dysregulation of CASP9 protein can lead to abnormal immune cell apoptosis, contributing to autoimmune diseases and immunodeficiency.

How is CASP9 protein targeted in cancer therapy? 09/06/2017

CASP9 protein is targeted using small molecule inhibitors and therapeutic antibodies to induce apoptosis in cancer cells.

Are there any genetic variations in the CASP9 gene that affect protein function? 08/18/2017

Yes, genetic variations in the CASP9 gene can impact protein function and have been linked to disease susceptibility.

Customer Reviews (3)

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Reviews
04/12/2023

    Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

    04/27/2020

      Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

      10/27/2016

        The bands of proteins in Western Blotting experiments were very clear.

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