Recombinant Rat Endonuclease G

• Cat.No.: Endog-623R
• Product Overview: Recombinant Rat Endonuclease G is produced in E. coli.

Specification

• Cat. No.: Endog-623R
• Description: Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
• Source: E. coli.
• Purity: ≥90% (SDS-PAGE).
• Concentration: 0.4mg/ml.
• Formulation: Liquid. In 50mM TRIS-HCl, pH 8.0, containing 500mM sodium chloride, 0.05% Tween 20, 5mM β-mercaptoethanol, 500mM imidazole and 20% glycerol.
• Application: For studying DNAS1L3 catalyzed oligonucleosomal DNA fragmentation.
• Storage And Stability: -80°C. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.

Gene Information

• Gene Name: Endog endonuclease G [ Rattus norvegicus ]
• Synonyms: Endog; endonuclease G
• Gene ID: 362100
• mRNA Refseq: NM_001034938
• Protein Refseq: NP_001030110
• UniProt ID: Q3V5X8
• Chromosome Location: 3p12
• Pathway: Apoptosis
• Function: endonuclease activity; hydrolase activity; metal ion binding; nucleic acid binding