Recombinant Human Deleted In Colorectal Carcinoma, GST-tagged

• Cat.No.: DCC-2110H
• Product Overview: Recombinant HumanDCC produced in inE. coli. The fibronectin domain 5 (FBN5) of human DCC (aa 841-941) is fused to a N-terminal GST-tag.

Specification

• Cat. No.: DCC-2110H
• Description: Deleted in Colorectal Carcinoma, also known as DCC is a tumor suppressor gene found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. DCC may participate in signaling pathways that regulate cell proliferation and/or differentiation, two cellular processes that often go awry during tumorigenesis. DCC is required for the formation of major axonal projections by embryonic cortical neurons, including the corpus callosum, hippocampal commissure, and cortico-thalamic tracts.
• Source: E. coli.
• Concentration: 1mg/ml after reconstitution.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
• Specificity: Binds to human and mouse netrin-1.
• Term Storage: -20°C.
• Handling: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Stability: Stable for at least 6 months after receipt when stored at -20°C.

Gene Information

• Gene Name: DCC deleted in colorectal carcinoma [ Homo sapiens ]
• Synonyms: DCC; deleted in colorectal carcinoma; CRC18; CRCR1; IGDCC1; netrin receptor DCC; colorectal tumor suppressor; colorectal cancer suppressor; tumor suppressor protein DCC; deleted in colorectal cancer protein; immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1
• Gene ID: 1630
• mRNA Refseq: NM_005215
• Protein Refseq: NP_005206
• MIM: 120470
• UniProt ID: P43146.1
• Chromosome Location: 18q21.3
• Pathway: Axon guidance; Colorectal cancer; Pathways in cancer
• Function: identical protein binding; netrin receptor activity; protein binding