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Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged

Cat. No.: PRMT6-653H
Product Overview: Recombinant Human Protein Arginine Methyltransferase 6 (NP_060607.2) (Met 1- Asp 375) was expressed, fused with a Flag tag at the N-terminus. It is expressed inHuman Cells.
Description: Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing.
Source: Human Cells.
Purity: >95 % as determined by SDS-PAGE.
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -700C.
Predicted N Terminal: Met.
Molecular Mass: The recombinant human PRMT6 consists of 394 amino acids and predictes a molecular mass of 44.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh PRMT6 is approximately 43 - 46 kDa.
Formulation: Supplied as a 0.2μm filtered solution of PBS, pH 7.5.
Storage: Store it under sterile conditions at -700C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Gene Name: PRMT6 protein arginine methyltransferase 6 [ Homo sapiens ]
Synonyms: PRMT6; protein arginine methyltransferase 6; HRMT1L6; FLJ10559; FLJ51477; EC 2.1.1.125; protein arginine N-methyltransferase 6; Histone-arginine methyltransferase PRMT6; EC 2.1.1.-; Protein arginine N-methyltransferase 6; HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae); Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
Gene ID: 55170
mRNA Refseq: NM_018137
Protein Refseq: NP_060607
MIM: 608274
UniProt ID: Q96LA8
Chromosome Location: 1p13.2
Function: histone binding; transferase activity; protein methyltransferase activity; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); histone methyltransferase activity (H4-R3 specific); protein methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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