Recombinant Human Golgi associated PDZ and coiled-coil motif containing, His-tagged GOPC-1941H

Recombinant Human Golgi associated PDZ and coiled-coil motif containing, His-tagged

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Recombinant Human Golgi associated PDZ and coiled-coil motif containing, His-tagged

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Cat. No. : GOPC-1941H
Product Overview : Recombinant human GOPC protein fused to his-tag was expressed inE.coliand purified by using conventional chromatography techniques. 21.5 kDa (198aa).
Description : GOPC, also known as PIST, is a PDZ domain-containing Golgi protein. This protein functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, GOPC is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding GOPC are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis.
Source : E.coli.
Purity : > 90% by SDS – PAGE.
Physical Appearance : Liquid.
Formulation : In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MIRKVLLLKE DHEGLGISIT GGK EHGVPIL ISEIHPGQPA DRCGGLHVGD AILAVNGVNL RDTKHKEAVT ILSQ QRGEIE FEVVYVAPEV DSDDENVEYE DESGHRYRLY LDEL EGGGNP GASCKDTSGE IKVLQGFNKK AVTDTHENGD LGTASETPLD DGASKLDDLH TLYHKKSY.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 2dc2. :

Gene Name : GOPC golgi-associated PDZ and coiled-coil motif containing [ Homo sapiens ]
Synonyms : GOPC; golgi associated PDZ and coiled-coil motif containing; CAL; FIG; PIST; GOPC1; AI844555; 2210402P09Rik; PDZ domain-containing protein PIST; PDZ protein interacting specifically with TC10; golgi-associated PDZ and coiled-coil motif-containing protein; dJ94G16.2; Fused in glioblastoma; CFTR-associated ligand; Golgi associated PDZ and coiled-coil motif containing protein; PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
Gene ID : 57120
mRNA Refseq : NM_001017408
Protein Refseq : NP_001017408
MIM : 606845
UniProt ID : Q9HD26
Chromosome Location : 6q21
Function : cystic fibrosis transmembrane conductance regulator binding; protein binding; small GTPase regulator activity

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