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Recombinant Human ERCC1

Cat. No.: ERCC1-2396H
Product Overview: Recombinant Human full lengthERCC1 (aa 448-568) is expressed inE.coli. MW=61kDa.
Description: The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3" of the DNA lesion while the ERCC1-XPF complex makes the 5" incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.
Source: E. coli.
Presentation: 100μl purified human MET protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
Application: ELISA, Inhibition Assays, Western Blotting.
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 61kDa including GST.
Storage: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name: ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) [ Homo sapiens ]
Synonyms: ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); UV20; COFS4; DNA excision repair protein ERCC-1
Gene ID: 2067
mRNA Refseq: NM_001166049
Protein Refseq: NP_001159521
MIM: 126380
UniProt ID: P07992
Chromosome Location: 19q13.2-q13.3
Pathway: Nucleotide excision repair; DNA Repair
Function: damaged DNA binding; endonuclease activity; hydrolase activity; protein C-terminus binding; protein domain specific binding; contributes_to single-stranded DNA specific endodeoxyribonuclease activity; contributes_to structure-specific DNA binding

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