"MAP3K8" Related Products

Recombinant Human MAP3K8, GST-His

Cat. No. : MAP3K8-636H
Product Overview : Recombinant human Cot/Tpl2 (a.a. 30-397) with N-terminal GST-His6-tag was expressed in aBaculovirus infected Sf9 cellexpression system. MW = 70 kDa.
Description : Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB.
Source : Baculovirus infected Sf9 cells.
Purity : >80%.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability : >6 months at –80°C.
Pathways : MAPK signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system
Gene Name : MAP3K8 mitogen-activated protein kinase kinase kinase 8 [ Homo sapiens ]
Synonyms : mitogen-activated protein kinase kinase kinase 8; COT; EST; ESTF; TPL2; MEKK8; Tpl-2; c-COT; FLJ10486; MAP3K8; proto-oncogene c-Cot; tumor progression locus 2; tumor progression locus-2; Ewing sarcoma transformant; Cancer Osaka thyroid oncogene; cot (cancer Osaka thyroid) oncogene; serine/threonine-protein kinase cot; proto-oncogene serine/threoine protein kinase; OTTHUMP00000019393; Ewing sarcoma transformant; OTTHUMP00000019392; TPL-2; Tumor progression locus 2; COT proto-oncogene serine/threonine-protein kinase; EC; C-COT
Gene ID : 1326
mRNA Refseq : NM_005204
Protein Refseq : NP_005195
MIM : 191195
UniProt ID : P41279
Chromosome Location : 10p11.23
Function : protein serine/threonine kinase activity; MAP kinase kinase kinase activity; ATP binding; magnesium ion binding; nucleotide binding; protein binding; transferase activity

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