||Recombinant human Cot/Tpl2 (a.a. 30-397) with N-terminal GST-His6-tag was expressed in aBaculovirus infected Sf9 cellexpression system. MW = 70 kDa.
||Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB.
||Baculovirus infected Sf9 cells.
||25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
||Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
||>6 months at –80°C.
||MAPK signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system