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Recombinant Human MAP2K1 protein, His-tagged

Cat.No. : MAP2K1-639H
Product Overview : Recombinant Human MAP2K1 fused with His tag at C-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His
Form : 45 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 10% glycerol, 200 mM imidazole, and 3 mM DTT.
Molecular Mass : 44.3 kDa
Purity : > 50 %
Applications : Useful as a substrate of cRAF (RAF1) and other kinases.
Storage : >6 months at -80 centigrade.
Gene Name : MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP2K1
Synonyms : MAP2K1; mitogen-activated protein kinase kinase 1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MAPKK1; MEK1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; MAP kinase kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); MKK1;
Gene ID : 5604
mRNA Refseq : NM_002755
Protein Refseq : NP_002746
MIM : 176872
UniProt ID : Q02750
Chromosome Location : 15q22.1-q22.33
Pathway : ARMS-mediated activation, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : ATP binding; MAP kinase kinase activity; Ras GTPase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; receptor signaling protein tyrosine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials targeting MAP2K1? 01/12/2023

Yes, there are clinical trials exploring the efficacy and safety of MAP2K1 inhibitors in various cancers and other diseases.

Are there diagnostic tests specifically targeting MAP2K1 in clinical practice? 01/10/2023

Some diagnostic tests may analyze MAP2K1 mutations, especially in the context of cancer, to inform treatment decisions.

What diagnostic applications does MAP2K1 have in cancer detection? 09/30/2019

MAP2K1 mutations can serve as biomarkers in cancer diagnostics, aiding in the identification and classification of tumors.

How does MAP2K1 contribute to drug resistance in cancer treatment? 06/14/2019

MAP2K1 mutations can be associated with resistance to certain cancer therapies, making it important to understand its role in treatment response.

Are there targeted therapies based on MAP2K1 in cancer treatment? 02/17/2016

Yes, MAP2K1 inhibitors are being explored as targeted therapies in cancer treatment, aiming to block the abnormal signaling associated with MAP2K1 mutations.

Customer Reviews (3)

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Reviews
08/01/2020

    The unmatched performance of the MAP2K1 protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.

    05/18/2016

      The MAP2K1 protein finds extensive utility in protein electron microscopy structure analysis.

      04/11/2016

        With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.

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