||Recombinant Mouse Fam3c was produced inHEK 293 cells.Mouse ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG-tag. MW = 25kDa.
||In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
||HEK 293 cells.
||Lyophilized. Contains PBS.
||0.1mg/ml after reconstitution.
||Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
||<0.1EU/µg purified protein (LAL test; Bio Whittaker).
||Stable for at least 6 months after receipt when stored at -20°C.