Recombinant Human PDE6D, His-tagged

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Recombinant Human PDE6D, His-tagged

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Cat. No. : PDE6D-2407H
Product Overview : Recombinant human PDE6D, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 18.4 kDa (158aa).
Description : Human PDE6D was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. Catalytically active PDE6 is a heterodimer (αβ) that is regulated by two inhibitory γ subunits. As PDE6D does not modify the catalytic properties of PDEαβ, its function is still unresolved.
Source : E.coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT, 100mM NaCl.
Purity : > 90% by SDS – PAGE.
Concentration : 0.5mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV GSHHHHHH.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1ksg. :

Gene Name : PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta [ Homo sapiens ]
Synonyms : phosphodiesterase 6D, cGMP-specific, rod, delta; PDED; PDE6D; retinal rod rhodopsin-sensitive cGMP 3",5"-cyclic phosphodiesterase subunit delta; protein p17; GMP-PDE delta; phosphodiesterase 6D; Protein p17
Gene ID : 5147
mRNA Refseq : NM_002601
Protein Refseq : NP_002592
MIM : 602676
UniProt ID : O43924
Chromosome Location : 2q35-q36
Pathway : Purine metabolism
Function : 3",5"-cyclic-nucleotide phosphodiesterase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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