Recombinant Human Ribosomal Protein S3, His-tagged

• Cat.No.: RPS3-2421H
• Product Overview: Recombinant human ribosomal protein S3 (aa 1-243) produced inE. coliis fused at the C-terminus to a His-tag.

Specification

• Cat. No.: RPS3-2421H
• Description: 40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage.
• Source/Host: E. coli.
• Purity: ≥90% (SDS-PAGE).
• Endotoxin Content: <1EU/µg protein (LAL-test).
• Formulation: Liquid. 0.2µm-filtered solution in 25mM TRIS-HCl, pH 8.5, containing 1mM DTT.
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: RPS3 ribosomal protein S3 [ Homo sapiens ]
• Synonyms: ribosomal protein S3; FLJ26283; FLJ27450; MGC87870; RPS3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3
• Gene ID: 6188
• mRNA Refseq: NM_001005
• Protein Refseq: NP_000996
• MIM: 600454
• UniProt ID: P23396
• Chromosome Location: 11q13.3-q13.5
• Pathway: Ribosome; Diabetes pathways; Gene Expression; Influenza Infection; Metabolism of proteins; Regulation of beta-cell development
• Function: DNA-(apurinic or apyrimidinic site) lyase activity; NF-kappaB binding; damaged DNA binding; endonuclease activity; iron-sulfur cluster binding; mRNA binding; protein binding; protein kinase binding; structural constituent of ribosome