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Recombinant Rat Renin, His-tagged

Cat. No.: Ren-2454R
Product Overview: Recombinant Rat Renin contains 381 amino acids and 8X-Histidine tag at C terminus. Fully activatable to renin by catalytic amounts of trypsin. Molecular weight is 41,849Da less glycosylation. It was produced inHEK.
Description: Renin is secreted from kidney cells (of the afferent arterioles), which are activated via signaling (the release of prostaglandins) from the macula densa, which respond to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by nervous stimulation, mainly through beta-1 receptor activation. A drop in the rate of flow past the macula densa implies a drop in renal filtration pressure. Renin"s primary function is therefore to eventually cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys.
Source: Human embryonic kidney cells.
Purification: >95% pure (SDS-PAGE). Chelated metal affinity chromatography.
Concentration: 1.4mg/ml (OD280nm, E0.1% = 1.13).
Format: Purified, Liquid.
Buffer: 50mM Tris, pH 8.0.
Preservative: None.
Applications: Specific methodologies have not been tested using this product.
Inactivation: Not applicable.
Storage: Store at -70ºC. Avoid multiple freeze/thaw cycles.
Gene Name: Ren renin [ Rattus norvegicus ]
Synonyms: Ren; rennin; Ren1; RENAA; RATRENAA; angiotensinogenase; renin 1 structural; renin 1
Gene ID: 24715
mRNA Refseq: NM_012642
Protein Refseq: NP_036774
UniProt ID: P08424
Chromosome Location: 13q13
Pathway: Renin-angiotensin system
Function: aspartic-type endopeptidase activity; aspartic-type endopeptidase activity; endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding

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