Recombinant Dog Renin, His-tagged REN-2456D

Recombinant Dog Renin, His-tagged

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Recombinant Dog Renin, His-tagged

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Cat. No. : REN-2456D
Product Overview : Recombinantly Dog Renin was produced inHEKcell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. MW = 41,570Da.
Description : Renin is secreted from kidney cells (of the afferent arterioles), which are activated via signaling (the release of prostaglandins) from the macula densa, which respond to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by nervous stimulation, mainly through beta-1 receptor activation. A drop in the rate of flow past the macula densa implies a drop in renal filtration pressure. Renin"s primary function is therefore to eventually cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys.
Source : Human Embryonic Kidney cells.
Concentration : 1.0 mg/ml.
Form : Frozen liquid.
Buffer : 0.05M Tris-HCl; pH 8.0.
Minimum Shelf Life : 3 years from delivery.
Storage : -70℃.
PDB rendering based on 2ren. :

Gene Name : REN renin [ Canis lupus familiaris ]
Synonyms : REN; rennin; rennin; angiotensinogenase; EC 3.4.23.15
Gene ID : 403838
mRNA Refseq : NM_001003194
Protein Refseq : NP_001003194
UniProt ID : Q6DYE7
Chromosome Location : 38
Pathway : Renin-angiotensin system

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