Recombinant Mouse Collagen, Type XVIII, Alpha 1
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Cat. No. : | Col18a1-204M |
Product Overview : | Recombinant mouse endostatin was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells. A 20 kDa C-terminal proteolytic fragment of collagen XVIII that specifically inhibits endothelial cell proliferation and potently inhibits angiogenesis and tumor growth. MW = 21397. |
Description : | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | S. frugiperda. |
Purity : | Single band by SDS-PAGE. |
Form : | Lyophilized from PBS, 10 mM citrate, pH 7.4. |
Solubility : | H2O. Please see vial label for concentration prior to lyophilization. |
Toxicity : | Standard Handling(MSDS available upon request). |
Storage : | ≤ -70℃. Protect from moisture. Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -20°C. |
PDB rendering based on 1bnl. : |
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Gene Name : | Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ] |
Synonyms : | Col18a1; collagen, type XVIII, alpha 1; endostatin; collagen alpha-1(XVIII) chain; OTTMUSP00000023764; OTTMUSP00000023766; procollagen, type XVIII, alpha 1 |
Gene ID : | 12822 |
mRNA Refseq : | NM_001109991 |
Protein Refseq : | NP_001103461 |
UniProt ID : | P39061 |
Chromosome Location : | 10 B5-C1; 10 41.3 cM |
Function : | Binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity |
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Col18a1 COL3A1 COL4A3 COL4A3BP COL6A1 COL17A1 COL1A1 COL4A1 COL7A1 COL15A1 COL20A1 COL23A1 COL4A6 COL5A1 COL6A2 COL2A1 COL14A1 COL1A2 COL25A1 COL5A3 COL9A1 COL9A3 COL24A1 COL8A1 COL10A1 COL11A2 COL4A2 COL11A1 COL13A1 COL21A1 COL8A2 COL5A2 COL12A1 COL22A1 COL9A2 COL19A1 COL16A1 COL27A1 COL28A1 Col4a4 Col4a5 COL6A3 Col6a4 Col6a5 Col6a6
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