| Cat. No. : | Col18a1-204M |
| Product Overview : | Recombinant mouse endostatin was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells. A 20 kDa C-terminal proteolytic fragment of collagen XVIII that specifically inhibits endothelial cell proliferation and potently inhibits angiogenesis and tumor growth. MW = 21397. |
| Description : | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : | S. frugiperda. |
| Purity : | Single band by SDS-PAGE. |
| Form : | Lyophilized from PBS, 10 mM citrate, pH 7.4. |
| Solubility : | H2O. Please see vial label for concentration prior to lyophilization. |
| Toxicity : | Standard Handling(MSDS available upon request). |
| Storage : | ≤ -70℃. Protect from moisture. Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -20°C. |
| PDB rendering based on 1bnl. : |
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| Gene Name : | Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ] |
| Synonyms : | Col18a1; collagen, type XVIII, alpha 1; endostatin; collagen alpha-1(XVIII) chain; OTTMUSP00000023764; OTTMUSP00000023766; procollagen, type XVIII, alpha 1 |
| Gene ID : | 12822 |
| mRNA Refseq : | NM_001109991 |
| Protein Refseq : | NP_001103461 |
| UniProt ID : | P39061 |
| Chromosome Location : | 10 B5-C1; 10 41.3 cM |
| Function : | Binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity |
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