Recombinant Mouse Collagen, Type XVIII, Alpha 1
Cat.No. : | Col18a1-204M |
Product Overview : | Recombinant mouse endostatin was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells. A 20 kDa C-terminal proteolytic fragment of collagen XVIII that specifically inhibits endothelial cell proliferation and potently inhibits angiogenesis and tumor growth. MW = 21397. |
- Specification
- Gene Information
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Cat. No. : | Col18a1-204M |
Description : | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | S. frugiperda. |
Purity : | Single band by SDS-PAGE. |
Form : | Lyophilized from PBS, 10 mM citrate, pH 7.4. |
Solubility : | H2O. Please see vial label for concentration prior to lyophilization. |
Toxicity : | Standard Handling(MSDS available upon request). |
Storage : | ≤ -70℃. Protect from moisture. Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -20°C. |
Gene Name : | Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ] |
Synonyms : | Col18a1; collagen, type XVIII, alpha 1; endostatin; collagen alpha-1(XVIII) chain; OTTMUSP00000023764; OTTMUSP00000023766; procollagen, type XVIII, alpha 1 |
Gene ID : | 12822 |
mRNA Refseq : | NM_001109991 |
Protein Refseq : | NP_001103461 |
UniProt ID : | P39061 |
Chromosome Location : | 10 B5-C1; 10 41.3 cM |
Function : | Binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity |
Products Types
◆ Recombinant Protein | ||
Col18a1-327M | Recombinant Mouse Col18a1 Protein, His-tagged | +Inquiry |
COL18A1-1274H | Recombinant Human COL18A1 Protein, His-tagged | +Inquiry |
COL18A1-1367H | Recombinant Human COL18A1 Protein (1578-1754 aa), His-tagged | +Inquiry |
Col18a1-1852M | Recombinant Mouse Col18a1 Protein, His (Fc)-Avi-tagged | +Inquiry |
COL18A1-326H | Recombinant Human COL18A1 Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.
COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.
Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.
COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.
COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.
Customer Reviews (3)
Write a reviewThe delivery was well-coordinated and timely.
Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.
The lab product showcases commendable quality.
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