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Recombinant Mouse Collagen, Type XVIII, Alpha 1

Cat.No. : Col18a1-204M
Product Overview : Recombinant mouse endostatin was fused to a His•Tag sequence and expressed inS. frugiperdainsect cells. A 20 kDa C-terminal proteolytic fragment of collagen XVIII that specifically inhibits endothelial cell proliferation and potently inhibits angiogenesis and tumor growth. MW = 21397.
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Cat. No. : Col18a1-204M
Description : This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.
Source : S. frugiperda.
Purity : Single band by SDS-PAGE.
Form : Lyophilized from PBS, 10 mM citrate, pH 7.4.
Solubility : H2O. Please see vial label for concentration prior to lyophilization.
Toxicity : Standard Handling(MSDS available upon request).
Storage : ≤ -70℃. Protect from moisture. Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -20°C.
Gene Name : Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ]
Synonyms : Col18a1; collagen, type XVIII, alpha 1; endostatin; collagen alpha-1(XVIII) chain; OTTMUSP00000023764; OTTMUSP00000023766; procollagen, type XVIII, alpha 1
Gene ID : 12822
mRNA Refseq : NM_001109991
Protein Refseq : NP_001103461
UniProt ID : P39061
Chromosome Location : 10 B5-C1; 10 41.3 cM
Function : Binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of COL18A1 in neurobiology, particularly its involvement in the central nervous system and potential implications for neurodegenerative disorders? 04/16/2021

COL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.

In angiogenesis, how does COL18A1 influence blood vessel formation, and what molecular mechanisms are involved in its regulation of endothelial cell behavior? 06/02/2020

COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.

What evidence supports the involvement of COL18A1 mutations in human diseases, and how do these mutations impact COL18A1 function and tissue homeostasis? 01/19/2019

Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.

How does COL18A1 contribute to the regulation of cellular senescence, and are there implications for age-related diseases and tissue degeneration? 12/30/2018

COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.

In cancer progression, how does COL18A1 influence tumor behavior, metastasis, and interactions with the tumor microenvironment? 08/11/2018

COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.

Customer Reviews (3)

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Reviews
06/01/2022

    The delivery was well-coordinated and timely.

    09/12/2019

      Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.

      12/23/2018

        The lab product showcases commendable quality.

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