Active Recombinant Human LCK, His-tagged
Cat.No. : | LCK-692H |
Product Overview : | Recombinant, human Lck fused to a His Tag sequence and expressed inS. frugiperda insect cells.Lck is a member of the Src tyrosine kinases that plays a role in T cell activation and in the regulation of mitochondrial apoptosis pathways. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Cat. No. : | LCK -692H |
Description : | LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers. |
Source : | S. frugiperda insect cells. |
Form : | Liquid. |
Formulation : | In 100 mM NaCl, 50 mM Tris-HCl, 1 mM DTT, 50 μM EDTA, 50% glycerol, 0.05% NP-40, pH 7.5. |
Molar Mass : | 60500 Da. |
Specific Activity : | ≥100 U/mg protein. |
Unit Definition : | One unit is defined as the amount of enzyme that will transfer 1.0 nmol phosphate to poly (Glu,Tyr) 4:1 substrate per min at 30°C, pH 7.5. |
Purity : | ≥90% by SDS-PAGE. |
Storage : | ≤ -70oC. Ship: Dry Ice Only. |
Gene Name : | LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ] |
Synonyms : | LCK; lymphocyte-specific protein tyrosine kinase; YT16; p56lck; pp58lck; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; EC 2.7.10.2; LSK; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase |
Gene ID : | 3932 |
mRNA Refseq : | NM_001042771 |
Protein Refseq : | NP_001036236 |
MIM : | 153390 |
UniProt ID : | P06239 |
Chromosome Location : | 1p34.3 |
Pathway : | Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; HIV Infection; Signaling in Immune system |
Function : | non-membrane spanning protein tyrosine kinase activity; ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; glycoprotein binding; nucleotide binding; phosphoinositide 3-kinase binding; protein C-terminus binding; protein kinase binding; protein serine/threonine phosphatase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
LCK-174H | Recombinant Human LCK Protein (SH3 Domain), GST tagged | +Inquiry |
LCK-3021R | Recombinant Rat LCK Protein, His (Fc)-Avi-tagged | +Inquiry |
Lck-1300M | Recombinant Mouse Lck Protein, MYC/DDK-tagged | +Inquiry |
LCK-173H | Active Recombinant Human LCK | +Inquiry |
LCK-573H | Active Recombinant Human LCK, GST-tagged | +Inquiry |
◆ Lysates | ||
LCK-681HCL | Recombinant Human LCK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket