Recombinant Human Annexin A5, FITC

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Recombinant Human Annexin A5, FITC

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Cat. No. : ANXA5-2625H
Product Overview : Recombinant Human Annexin A5-FITC is expressed inE. coli.
Description : Annexin 5 is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. In vitro studies have shown that Annexin 5 is a cellular protein which plays a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin. Through affinity assays Annexin 5 has been localized on cells that expressed phosphatidylserine on the cell surface, a feature found in apoptosis as well as other forms of cell death.
Source : E. coli.
Purity : >98% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
Molecular Weight : 35.8 kDa.
Presentation : Solution containing 50 mM TRIS, 100 mM NaCl, 1% BSA, 0.02% Sodium Azide, pH 7.4.
Biological Activity : Annexin V exhibits anti-phospholipase activity and binds to phosphatidylserine (PS).
Application : FITC labelling allows simple direct detection of PS by FACS analysis. Counterstaining by propidium iodide allows the discrimination of apoptotic cells.
Storage : Stable at 2°-8°C as indicated on the label. Do not freeze!
PDB rendering based on 1a8a. :

Gene Name : ANXA5 annexin A5 [ Homo sapiens ]
Synonyms :
ANXA5; annexin A5; PP4; ANX5; ENX2; anchorin CII; endonexin II; lipocortin V; placental anticoagulant protein I; Annexin-5; Annexin V; Lipocortin V; Endonexin II; Calphobindin I; Placental anticoagulant protein I; Placental anticoagulant protein 4; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha; CBP-I; PAP-I
Gene ID : 308
mRNA Refseq : NM_001154
Protein Refseq : NP_001145
MIM : 131230
UniProt ID : P08758
Chromosome Location : 4q27
Function : calcium ion binding; calcium-dependent phospholipid binding; eukaryotic cell surface binding; phospholipase inhibitor activity; protein binding; receptor tyrosine kinase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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