Cat.No. : | Hmgb1-2628M |
Product Overview : | Recombinant Mouse Hmgb1(Met1-Glu215) fused with His tag at N-terminal was expressed in E. coli. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Sterile liquid; 20 mM Tris-HCl, pH 8.0, 0.2 M NaCl, 1 mM DTT. 0.22 um filtered. |
Bio-activity : | The ED50 of this protein, as measured by mouse TNF alpha induction in RAW264.7 cells, is 3-25 ug/mL in the presence of 10 ug/mL Polymyxin B. This corresponds to a specific activity of 3,300-40 Units/mg. |
Molecular Mass : | Has a predicted molecular mass of 27.6 kDa. |
Endotoxin : | Less than 0.01 ng/ug cytokine as determined by the LAL assay. |
Purity : | > 98%, as determined by SDS-PAGE |
Storage : | Store at less than or equal to -70 centigrade. |
Concentration : | 0.5 mg/mL |
Gene Name : | Hmgb1 high mobility group box 1 [ Mus musculus ] |
Official Symbol : | Hmgb1 |
Synonyms : | HMGB1; high mobility group box 1; high mobility group protein B1; high mobility group protein 1; DEF; p30; Hmg1; HMG-1; SBP-1; amphoterin; MGC103168; MGC103169; MGC117896; MGC117897; |
Gene ID : | 15289 |
mRNA Refseq : | NM_010439 |
Protein Refseq : | NP_034569 |
MIM : | |
UniProt ID : | P63158 |
Chromosome Location : | 5 G3; 5 89.18 Cm |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of DNA fragmentation factor, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Base excision repair, organism-specific biosystem; |
Function : | 5S rRNA binding; DNA binding; DNA binding, bending; RAGE receptor binding; bent DNA binding; binding; calcium-dependent protein kinase regulator activity; crossed form four-way junction DNA binding; cytokine activity; cytokine activity; double-stranded DNA binding; four-way junction DNA binding; glycolipid binding; heparin binding; open form four-way junction DNA binding; peptide binding; |
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