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Recombinant Human Angiogenin, Ribonuclease, RNase A Family, 5

Cat. No.: ANG-2629H
Product Overview: Recombinant human angiogenin is expressed inE. coli.Exhibits angiogenic and ribonucleolytic activities. Enhances the ability of endothelial cells to digest extracellular matrix components and degrade basement membrane. Has been shown to stimulate capillary and umbilical vein endothelial cells to produce DAG and secrete prostacyclin by phospholipase activation.
Description: Angiogenin (Ang) is a small polypeptide that is implicated in angiogenesis (formation of new blood vessels) in tumor growth. However, angiogenin is unique among the many proteins that are involved in angiogenesis in that it is also an enzyme with an amino acid sequence 33% identical to that of bovine pancreatic ribonuclease (RNase) A. Moreover, although Ang has the same general catalytic properties as RNase A – it cleaves preferentially on the 3" side of pyrimidines and follows a transphosphorylation/hydrolysis mechanism – its activity differs markedly both in magnitude and in specificity.
Source: E. coli.
Form: Liquid.
Formulation: Lyophilized from sterile-filtered PBS containing 50 μg BSA/μg Angiogenin.
Molar Mass: 14000Da.
Purity: ≥95% by SDS-PAGE.
Endotoxins: ≤100 pg/μg Angiogenin.
Storage: ≤ -70oC. Ship: Dry Ice Only.
Gene Name: ANG angiogenin, ribonuclease, RNase A family, 5 [ Homo sapiens ]
Synonyms:
ANG; angiogenin, ribonuclease, RNase A family, 5; RNase 5; angiogenin; epididymis luminal protein 168; ribonuclease 5; ALS9; HEL168; RNASE4; RNASE5; MGC22466; MGC71966; EC 3.1.27.-
Gene ID: 283
mRNA Refseq: NM_001097577
Protein Refseq: NP_001091046
MIM: 105850
UniProt ID: P03950
Chromosome Location: 14q11.1-q11.2
Function: DNA binding; actin binding; copper ion binding; endonuclease activity; heparin binding; hydrolase activity; pancreatic ribonuclease activity; ribonuclease activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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