"IGF1R" Related Products

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Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His

Cat. No. : IGF1R-2654H
Product Overview : Recombinant human IGF-1R was fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed inS. frugiperdainsect cells using a baculovirus expression system. MW = 76532 Da.
Description : IGF-1R belong to the tyrosine kinase receptor family that mediates cell survival and growth in response to its ligands, IGF-1 and IGF-2. It is also involved in the proliferation of transformed cells.
Source : S. frugiperda.
Form : Liquid. In 100 mM NaCl, 50 mM Tris-HCL, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Specific Activity : ≥45 U/mg protein.
Unit Definition : One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Glu,Tyr)4:1 per min at 30°C using variable concentrations of ATP (0.1-2.52 µM).
Storage : ≤ -70℃. Avoid freeze/thaw.
Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
Synonyms : IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
Gene ID : 3480
mRNA Refseq : NM_000875
Protein Refseq : NP_000866
MIM : 147370
UniProt ID : P08069
Chromosome Location : 15q26.3
Pathway : Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer
Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity

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