|Product Overview:||Recombinant Human NCF4 was produced inE.coliwith a T7 tag at N-terminus. MW = 39032 Da (1-348 aa).|
|Description:||Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.|
|Form:||10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.|
|Gene Name:||NCF4 neutrophil cytosolic factor 4, 40kDa [ Homo sapiens ]|
|Synonyms:||NCF4; neutrophil cytosolic factor 4, 40kDa; NCF; MGC3810; P40PHOX; SH3PXD4; NCF-4; p40-phox; neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; neutrophil cytosolic factor 4 (40kD)|
|Pathway:||Leishmaniasis; Leukocyte transendothelial migration; Phagosome|
|Function:||phosphoinositide binding; protein binding; protein dimerization activity|
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