"NCF4" Related Products


Recombinant Human Neutrophil Cytosolic Factor 4, 40kDa, T7-tagged

Cat. No.: NCF4-2953H
Product Overview: Recombinant Human NCF4 was produced inE.coliwith a T7 tag at N-terminus. MW = 39032 Da (1-348 aa).
Description: Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Source: E.coli.
Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
Purity: 95%.
Applications: MS. SDS.
Gene Name: NCF4 neutrophil cytosolic factor 4, 40kDa [ Homo sapiens ]
Synonyms: NCF4; neutrophil cytosolic factor 4, 40kDa; NCF; MGC3810; P40PHOX; SH3PXD4; NCF-4; p40-phox; neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; neutrophil cytosolic factor 4 (40kD)
Gene ID: 4689
mRNA Refseq: NM_000631
Protein Refseq: NP_000622
MIM: 601488
UniProt ID: Q15080
Chromosome Location: 22q13.1
Pathway: Leishmaniasis; Leukocyte transendothelial migration; Phagosome
Function: phosphoinositide binding; protein binding; protein dimerization activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.