Recombinant Human Neutrophil Cytosolic Factor 4, 40kDa, T7-tagged
Cat.No. : | NCF4-2953H |
Product Overview : | Recombinant Human NCF4 was produced inE.coliwith a T7 tag at N-terminus. MW = 39032 Da (1-348 aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | NCF4-2953H |
Description : | Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Source : | E.coli. |
Form : | 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT. |
Purity : | 95%. |
Applications : | MS. SDS. |
Gene Name : | NCF4 neutrophil cytosolic factor 4, 40kDa [ Homo sapiens ] |
Synonyms : | NCF4; neutrophil cytosolic factor 4, 40kDa; NCF; MGC3810; P40PHOX; SH3PXD4; NCF-4; p40-phox; neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; neutrophil cytosolic factor 4 (40kD) |
Gene ID : | 4689 |
mRNA Refseq : | NM_000631 |
Protein Refseq : | NP_000622 |
MIM : | 601488 |
UniProt ID : | Q15080 |
Chromosome Location : | 22q13.1 |
Pathway : | Leishmaniasis; Leukocyte transendothelial migration; Phagosome |
Function : | phosphoinositide binding; protein binding; protein dimerization activity |
Products Types
◆ Recombinant Protein | ||
NCF4-3592H | Recombinant Human NCF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
NCF4-180H | Recombinant Human NCF4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Ncf4-4310M | Recombinant Mouse Ncf4 Protein, Myc/DDK-tagged | +Inquiry |
NCF4-5939M | Recombinant Mouse NCF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
NCF4-519H | Recombinant Human NCF4 | +Inquiry |
◆ Lysates | ||
NCF4-3949HCL | Recombinant Human NCF4 293 Cell Lysate | +Inquiry |
NCF4-3948HCL | Recombinant Human NCF4 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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