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Active Recombinant Equine IL4

Cat.No. : IL4-256E
Product Overview : Equine IL-4 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.
Source : Yeast
Species : Equine
Form : Lyophilized without carrier protein.
Bio-activity : The biological activity of recombinant equine IL-4 was measured in a cell proliferation assay using the human TF-1 cell line. The ED50 for this effect is typically 40-60 ng/mL.
Molecular Mass : Equine IL-4 has a predicted molecular weight of 12.8 kDa.
AA Sequence : GCKYDITLQE IIKTLNNLTD GKGKNSCMEL TVADAFAGPK NTDGKEICRA AKVLQQLYKR HDRSLIKECL SGLDRNLKGM ANGTCCTVNE AKKSTLKDFL ERLKTIMKEK YSKC (114)
Purity : >95% as visualized by SDS-PAGE analysis.
Applications : The Equine IL-4 protein can be used in cell culture, as an IL-4 ELISA Standard, and as a Western Blot Control.
Storage : Stable for up to twelve months from date of receipt at -20oC. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20oC. Avoid repeated freeze/thaw cycles.
Reconstitution : Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Gene Name : IL4 interleukin 4 [ Equus caballus (horse) ]
Official Symbol : IL4
Synonyms : IL4; interleukin 4; IL-4; BSF-1; interleukin-4; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1
Gene ID : 100034225
mRNA Refseq : NM_001082519
Protein Refseq : NP_001075988
UniProt ID : P42202
Chromosome Location : 14
Function : Allograft rejection; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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10/17/2021

    By testing immunogenicity in animal models, detect whether an immune response is induced.

    11/09/2020

      The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

      05/06/2020

        This protein has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

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