Active Recombinant Mouse Map2k1, GST-tagged
Cat.No. : | Map2k1-666M |
Product Overview : | Recombinant full-length mouse MEK1 (S218E, S222E) was expressed in E. coli cells using a N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | MEK1 (EE) is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer. |
Source : | E.coli |
Species : | Mouse |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 326 nmol/min/mg |
Molecular Mass : | ~69 kDa |
Protein length : | Full Length |
Purity : | >70% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1 yr at -70°C from date of shipment. |
Storage : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ul |
Gene Name : | Map2k1 mitogen-activated protein kinase kinase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Map2k1 |
Synonyms : | Map2k1; mitogen-activated protein kinase kinase 1; Mek1; MEKK1; MAPKK1; Prkmk1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; MAP kinase kinase 1; ERK activator kinase 1; mitogen activated protein kinase kinase 1; protein kinase, mitogen activated, kinase 1, p45; NP_032953.1; EC 2.7.12.2 |
Gene ID : | 26395 |
mRNA Refseq : | NM_008927 |
Protein Refseq : | NP_032953 |
UniProt ID : | P31938 |
Chromosome Location : | 9 C; 9 34.55 cM |
Pathway : | ARMS-mediated activation; Activated TLR4 signalling; Acute myeloid leukemia; Androgen Receptor Signaling Pathway |
Function : | ATP binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding |
Products Types
◆ Recombinant Protein | ||
Map2k1-3920M | Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged | +Inquiry |
MAP2K1-2483R | Recombinant Rhesus Macaque MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K1-3430H | Recombinant Human MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K1-1307M | Recombinant Mouse MAP2K1 protein(Met1-Ile393) | +Inquiry |
MAP2K1-3215R | Recombinant Rat MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MAP2K1-001MCL | Recombinant Mouse MAP2K1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1614 | MEK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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