Recombinant Human CTSA protein(Met1-Tyr480), His-tagged
Cat.No. : | CTSA-895H |
Product Overview : | Recombinant Human cathepsin A isoform b (Met 1-Tyr 480) (NP_001121167.1) was expressed in HEK293 with a N-terminal signal peptide and a C-terminal polyhistidine tag. |
- Specification
- Gene Information
- Related Products
Source : | HEK293 |
Species : | Human |
Tag : | C-His |
Protein length : | Met1-Tyr480 |
Form : | Lyophilized from sterile 25mM Tris, 0.15mM NaCl, pH 7.8. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The secreted recombinant human CTSA existing as a single-chain form consists of 463 amino acids and has a predicted molecular mass of 53 kDa as estimated by SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | CTSA cathepsin A [ Homo sapiens ] |
Official Symbol : | CTSA |
Synonyms : | CTSA; cathepsin A; GSL, PPGB, protective protein for beta galactosidase (galactosialidosis); lysosomal protective protein; carboxypeptidase C; carboxypeptidase Y like kininase; carboxypeptidase L; deamidase; lysosomal carboxypeptidase A; urinary kininase; carboxypeptidase-L; beta-galactosidase 2; protective protein cathepsin A; carboxypeptidase Y-like kininase; beta-galactosidase protective protein; GSL; GLB2; NGBE; PPCA; PPGB; |
Gene ID : | 5476 |
mRNA Refseq : | NM_000308 |
Protein Refseq : | NP_000299 |
MIM : | 613111 |
UniProt ID : | P10619 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (7)
Ask a questionPost-translational modifications of CTSA are not well-documented, requiring further research for comprehensive understanding.
CTSA has roles in various cellular processes outside the lysosome, though these are less well understood compared to its lysosomal functions.
CTSA is crucial for the catabolism of glycoproteins, aiding in the removal of terminal sugar moieties.
Therapeutic strategies for CTSA-related disorders are in the early stages of development, with enzyme replacement therapy being a potential avenue.
Dysfunction or deficiency in CTSA leads to Galactosialidosis, characterized by the accumulation of sialyloligosaccharides and glycoproteins in tissues.
It forms a complex with β-galactosidase and neuraminidase, preventing their premature degradation and facilitating their activation.
CTSA acts as a protective protein, ensuring the stability and proper function of other lysosomal enzymes.
Customer Reviews (3)
Write a reviewProduct arrived quickly, undamaged.
Great results, worth buying.
Highly pure, excellent product.
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