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Recombinant Human CTSA protein(Met1-Tyr480), His-tagged

Cat.No. : CTSA-895H
Product Overview : Recombinant Human cathepsin A isoform b (Met 1-Tyr 480) (NP_001121167.1) was expressed in HEK293 with a N-terminal signal peptide and a C-terminal polyhistidine tag.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Met1-Tyr480
Form : Lyophilized from sterile 25mM Tris, 0.15mM NaCl, pH 7.8. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant human CTSA existing as a single-chain form consists of 463 amino acids and has a predicted molecular mass of 53 kDa as estimated by SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CTSA cathepsin A [ Homo sapiens ]
Official Symbol : CTSA
Synonyms : CTSA; cathepsin A; GSL, PPGB, protective protein for beta galactosidase (galactosialidosis); lysosomal protective protein; carboxypeptidase C; carboxypeptidase Y like kininase; carboxypeptidase L; deamidase; lysosomal carboxypeptidase A; urinary kininase; carboxypeptidase-L; beta-galactosidase 2; protective protein cathepsin A; carboxypeptidase Y-like kininase; beta-galactosidase protective protein; GSL; GLB2; NGBE; PPCA; PPGB;
Gene ID : 5476
mRNA Refseq : NM_000308
Protein Refseq : NP_000299
MIM : 613111
UniProt ID : P10619

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any post-translational modifications that regulate CTSA activity? 06/12/2022

Post-translational modifications of CTSA are not well-documented, requiring further research for comprehensive understanding.

How does CTSA influence cellular processes outside the lysosome? 04/04/2022

CTSA has roles in various cellular processes outside the lysosome, though these are less well understood compared to its lysosomal functions.

What is the significance of CTSA in the degradation of glycoproteins? 03/24/2022

CTSA is crucial for the catabolism of glycoproteins, aiding in the removal of terminal sugar moieties.

What therapeutic strategies are being explored to address deficiencies or dysfunctions in CTSA? 01/27/2022

Therapeutic strategies for CTSA-related disorders are in the early stages of development, with enzyme replacement therapy being a potential avenue.

How is CTSA dysfunction associated with Galactosialidosis? 04/28/2020

Dysfunction or deficiency in CTSA leads to Galactosialidosis, characterized by the accumulation of sialyloligosaccharides and glycoproteins in tissues.

How does CTSA contribute to the stability and activation of other lysosomal enzymes? 10/29/2019

It forms a complex with β-galactosidase and neuraminidase, preventing their premature degradation and facilitating their activation.

What is the primary function of CTSA in the lysosome? 10/07/2019

CTSA acts as a protective protein, ensuring the stability and proper function of other lysosomal enzymes.

Customer Reviews (3)

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Reviews
06/12/2022

    Product arrived quickly, undamaged.

    04/04/2022

      Great results, worth buying.

      01/27/2022

        Highly pure, excellent product.

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