Recombinant Human GFRA2 protein, His-tagged
Cat.No. : | GFRA2-3162H |
Product Overview : | Recombinant Human GFRA2 (Ser22-Ser441) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | GDNF family receptor alpha-2 (GFRA2) is also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser22 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 47.6 kDa. The protein migrates as 60-70 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Ser22-Ser441 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >97% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | GFRA2 |
Official Symbol : | GFRA2 |
Synonyms : | GFRA2; GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNFRB; NTNRA; RETL2; TRNR2; GDNFR-beta; NTNR-alpha; GFR-alpha 2; RET ligand 2; GDNFR-alpha-2; GDNF receptor beta; neurturin receptor alpha; TRN receptor, GPI-anchored; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 2; glial cell line derived neurotrophic factor receptor, beta; NRTNR-ALPHA |
Gene ID : | 2675 |
mRNA Refseq : | NM_001165038 |
Protein Refseq : | NP_001158510 |
MIM : | 601956 |
UniProt ID : | O00451 |
Products Types
◆ Recombinant Protein | ||
GFRA2-81H | Recombinant Human GFRA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gfra2-10560M | Recombinant Mouse Gfra2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gfra2-360M | Recombinant Mouse Gfra2 Protein, His-tagged | +Inquiry |
GFRA2-266H | Recombinant Human GFRA2 Protein, His-tagged | +Inquiry |
GFRA2-359H | Recombinant Human GFRA2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GFRA2-2408MCL | Recombinant Mouse GFRA2 cell lysate | +Inquiry |
GFRA2-2425HCL | Recombinant Human GFRA2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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