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Recombinant Human HSD17B11, 20-285 aa, His-tagged

Cat. No.: HSD17B11-943H
Product Overview: Recombinant human HSD17B11 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 31.4 kDa (287aa).
Description: HSD17B11, also known as DHRS8 (dehydrogenase/reductase SDR family member 8), belongs to the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. It is widely expressed with highest levels found in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells. This protein converts androstan-3-α,17-β-diol (3-α-diol) to androsterone, suggesting it may participate in androgen metabolism during steroidogenesis.
Source: E.coli.
Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
Purity: > 95% by SDS - PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MESFVKLFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 [ Homo sapiens ]
Synonyms: hydroxysteroid (17-beta) dehydrogenase 11; DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; HSD17B11; estradiol 17-beta-dehydrogenase 11; 17-BETA-HSD11; 17-BETA-HSDXI; 17-beta-HSD 11; 17-beta-HSD XI; OTTHUMP00000219651; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; T-cell lymphoma-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; 17-beta-hydroxysteroid dehydrogenase type XI; dehydrogenase/reductase (SDR family) member 8; retinal short-chain dehydrogenase/reductase 2; cutaneous T-cell lymphoma-associated antigen HD-CL-03; short chain dehydrogenase/reductase family 16C, member 2; EC 1.1.1.62
Gene ID: 51170
mRNA Refseq: NM_016245
Protein Refseq: NP_057329
MIM: 612831
UniProt ID: Q8NBQ5
Chromosome Location: 4q22.1
Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activity; binding

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