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Recombinant Human NRP1 protein, Fc-tagged

Cat.No. : NRP1-3346H
Product Overview : Recombinant Human NRP1 (Phe22-Lys644) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Phe22
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 96.5 kDa. The protein migrates as 105-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Phe22-Lys644
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : NRP1
Official Symbol : NRP1
Synonyms : NRP1; neuropilin 1; neuropilin-1; CD304; NRP; VEGF165R; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; NP1; BDCA4; DKFZp781F1414; DKFZp686A03134
Gene ID : 8829
mRNA Refseq : NM_001024628
Protein Refseq : NP_001019799
MIM : 602069
UniProt ID : O14786

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the role of NRP1 in lung disease? 12/01/2022

It may be involved in the processes of angiography, inflammation, fibrosis and other processes in the lungs, and is related to the occurrence and development of lung diseases.

What factors are associated with high NRP1 expression? 01/02/2022

The high expression of NRP1 may be related to factors such as the aggressiveness of the tumor and the increased angiogenesis of the tumor.

Can NRP1 be targeted for targeted therapy? 03/02/2021

Yes, NRP1, as a molecule with important biological functions and clinical significance, can be targeted as a target therapy.

What are the applications of NRP1 in clinical diagnosis? 10/29/2020

This protein can be used as a potential marker in clinical diagnosis for tumor diagnosis and prognosis evaluation.

Is NRP1 associated with drug therapy? 04/18/2020

Yes, NRP1 may be related to the metabolism of drugs, the response to drug treatment, etc., which affects the efficacy and side effects of drugs.

How is NRP1 related to immune diseases? 04/07/2020

NRP1 may be involved in the regulation of autoimmune responses, inflammatory responses, etc., and is related to the occurrence and development of immune diseases.

Customer Reviews (3)

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05/24/2022

    The protein has a moderate molecular weight and is convenient to use.

    07/12/2021

      NRP1 can be easily used and measured in experiment.

      04/20/2021

        NRP1 has a high purity.

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